Appian Life Sciences and Supply Chain Industry Leaders describe a low-code platform approach to drive agility and enhance resilience in the face of the current trends accelerated by the pandemic. There was always the need to boost communications, tighten controls, and enable teams to have the right information available at the appropriate time to make rapid decisions, however, with the jarring impacts of the past year new innovative approaches are needed. These approaches include moving from legacy hardened processes to building organizational capacity to build, test, and learn in rapid succession and develop the resilience to an ever changing ecosystem.